Error 10053 can be caused by McAfee VirusScan Enterprise 8 when sending outgoing
email from Ace Payroll.
By default McAfee VirusScan 8 blocks all outgoing messages sent by any program that it does not recognise. This is intended to stop email worms from sending out
messages, but it also stops Ace Payroll from sending messages.
To solve this problem you need to tell McAfee that Ace Payroll is a "trusted" program for sending emails. To do this:
Right-click the McAfee "shield" in the task tray
Choose VirusScan Console
Then, double-click Access Protection
Go to the Port Blocking tab
In the Ports to Block section, select Prevent mass mailing worms from sending email and press Edit